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. 2020 Jun 28;24(15):8545–8556. doi: 10.1111/jcmm.15480

FIGURE 6.

FIGURE 6

The association between miR‐146a and COX2 was identified by the putative binding site on 3’UTR of COX2 mRNA (A) and the evidently decreased relative luciferase activity of wild‐type COX2 mRNA in T24 cells (B) or RT4 cells (C) transfected with miR‐146a; moreover, YAP1 mRNA was validated to be a target gene of miR‐146a by detecting a potential binding site of on 3’UTR of YAP1 mRNA (D) and the suppressed relative luciferase activity of wild‐type YAP1 mRNA in T24 cells (E) or RT4 cells (F) transfected with miR‐146a (*P value < 0.01 vs control + WT COX2 group; **P value < .01 vs control + WT YAP1 group; WT, wild‐type; MUT, mutant)