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. 2020 Jul 11;24(15):8589–8602. doi: 10.1111/jcmm.15487

Figure 1.

Figure 1

Up‐regulated LINC00160 is associated with chemotherapeutic drug resistance in BC. A, Microarray analysis was performed to determine differentially expressed lncRNAs between BC and adjacent normal tissue. B, RT‐qPCR were performed to determine LINC00160, LINC00558, LINC00260, LINC00597 and LINC01278 expression in 47 BC patients C, LINC00160 expression in paclitaxel‐resistant tumour tissue (n = 22) and in paclitaxel‐sensitive tumour tissue (n = 25) determined using RT‐qPCR. Unpaired t test was used for data analysis. D, Kaplan‐Meier survival curves were used to reflect the OS of BC patients. E ~ F, Viability of the parental MCF‐7, MCF‐7/Tax, parental BT474 and BT474/Dox cells detected using CCK‐8 assays. Two‐way ANOVA was used to determine statistical significance. G, LINC00160 expression in MCF10A cells, parental drug‐sensitive MCF‐7 and BT474 cells, and in MCF‐7‐Tax and BT474/Dox cells determined via RT‐qPCR. One‐way ANOVA was used to determine statistical significance. Data are expressed as mean ± s.d., representative of three independent experiments. **P < .01