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. 2020 Jul 11;24(15):8589–8602. doi: 10.1111/jcmm.15487

Figure 6.

Figure 6

LINC00160 mediates paclitaxel and doxorubicin resistance in MCF‐7 cells by up‐regulating TFF3 via C/EBPβ. A, TFF3 expression determined by RT‐qPCR and Western blot analyses, normalized to GAPDH expression. B, Cell viability of parental MCF‐7, MCF‐7/Tax, parental BT474 and BT474/Dox cells measured by CCK‐8 assays. C, Representative views of colonies from parental MCF‐7, MCF‐7/Tax, parental BT474 and BT474/Dox cells evaluated by clonogenic assays. D, Representative views of apoptotic cells from parental MCF‐7, MCF‐7/Tax, parental BT474 and BT474/Dox cells evaluated by Hoechst 33258 staining. One‐way or two‐way ANOVA was used to determine statistical significance. Data are expressed as mean ± s.d., representative of three independent experiments. *P < .05 vs empty vector group; # < 0.05 vs si‐NC group