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. 2020 Jul 23;20(4):37. doi: 10.3892/ol.2020.11896

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Copyright: © Javed et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — lncRNA-based modulation of gene expression via epigenetic modification. lncRNA can induce (A) gene activation or (B) suppression by inducing histone demethylation and histone methylation, respectively. Histone modification further allows recruitment of transcription factors or transcription repressor to the promoter region according to the fate of the gene. (C) and (D) lncRNAs also induce chromatin modification for silencing or promoting expression of gene. lncRNA, long non-coding RNA.