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Gene Silencing Mechanism Induced by HOTAIR
HOTAIR interacts with PRC2 and LSD1 complexes to recruit them to target genes. PRC2 trimethylated histone H3K27 and LSD1 induced H3K4 demethylation, which silenced the target gene. BRCA1 can compete with HOTAIR to combine PRC2 and inhibit the combination of HOTAIR and PRC2. CDK1/2 mediates the phosphorylation of PRC2 and promotes HOTAIR activation.
