Table II.
Methylation of the CpG sites in the INS gene promoter.
| Methylation, %a | |||
|---|---|---|---|
| CpG siteb | T1D, n=20 | Control group, n=20 | P-value |
| Mean methylation (range) | 84.13±3.6 (77-92) | 82.28±2.8 (76-87) | 0.084 |
| 1/-357 | 94.00±5.0 | 90.78±7.9 | 0.15 |
| 2/-345 | 96.32±2.2 | 93.28±4.5 | 0.02 |
| 3/-234 | 91.02±6.3 | 89.58±8.4 | 0.65 |
| 4/-206 | 63.16±8.9 | 62.30±9.8 | 0.86 |
| 5/-180 | 85.78±6.6 | 84.35±9.9 | 0.82 |
| 6/-135 | 56.65±9.8 | 52.82±1.0 | 0.25 |
| 7/-102 | 90.01±3.6 | 86,53±6,0 | 0.06 |
| 8/-69 | 80.28±6.2 | 77.72±8.4 | 0.32 |
| 9/-19 | 91.51±5.2 | 89.05±9.2 | 0.67 |
| 10/+60 | 96.37±2.7 | 97.91±1.3 | 0.1 |
aMean ± standard deviation.
bCpG sites are indicated by the first number and the second numbering indicates the actual sites of the INS gene promoter region proximal to TSS. T1D, Type 1 Diabetes; CpG site, Cytosine-Guanine site; INS, insulin gene.