Table III.

Correlation matrix of the methylation values at various CpG sites of the INS gene promoter among T1D patients.

CpG site	-357	-345	-234	-206	-180	-135	-102	-69	-19	60
INS-357		0.241	0.453a	0.081	0.356	0.480a	0.420	0.191	0.430	-0.020
		0.307	0.045	0.734	0.123	0.032	0.066	0.420	0.058	0.935
INS-345			0.346	0.083	0.030	0.011	-0.186	0.298	0.195	0.090
			0.135	0.729	0.900	0.965	0.431	0.202	0.409	0.705
INS-234				0.451a	0.487a	0.215	0.105	0.259	-0.092	0.105
				0.046	0.029	0.363	0.659	0.271	0.701	0.659
INS-206					0.400	0.223	0.314	0.271	-0.117	0.223
					0.081	0.346	0.177	0.248	0.622	0.346
INS-180						0.328	0.153	0.021	-0.012	0.408
						0.158	0.519	0.930	0.960	0.075
INS-135							0.395	0.138	0.323	0.069
							0.084	0.561	0.164	0.772
INS-102								0.095	0.141	0.029
								0.691	0.552	0.905
INS-69									0.068	0.245
									0.777	0.298
INS-19										-0.176
										0.458

Spearman's Rho R-value (upper), Spearman's Rho P-value (lower).

^aP<0.05. CpG site, Cytosine-Guanine site; T1D, Type 1 Diabetes; INS, insulin gene.