Estimated marginal means/probabilities (Average Marginal Effects; AMEs) and 95% confidence intervals for age modifications in the associations between cardiovascular risk scores and cognitive function (z-scores for continuous outcomes). Results are derived from survey generalized linear models. Results for Hispanic/Latino adults ages 45–74 years without prevalent stroke or cardiovascular events (HCHS/SOL; 2008–2011). FCRS, Framingham Cardiovascular Risk Score; GVRS, Global Vascular Risk Score; Global Cognition, Composite factor score; SIS, Six-item Screener; B-SEVLT, Spanish English verbal learning test; WF, word fluency; DSS, digit symbol substitution. Models are adjusted for education, Hispanic/Latino background, CESD-10, and study site adjustments. (a) Global cognitive outcomes (b) Domain specific cognitive function.