. Author manuscript; available in PMC: 2020 Aug 7.

Published in final edited form as: J Alzheimers Dis. 2020;73(1):103–116. doi: 10.3233/JAD-190830

Table 2.

Associations between cardiovascular risk scores and cognitive function (z-scores for continuous outcomes). Results are derived from survey generalized linear models. Results for Hispanic/Latino adults ages 45–74 years without prevalent stroke or cardiovascular events (HCHS/SOL; 2008–2011)

Primary outcomes

	M1 GC	M2 GC
	β (se)	β (se)
FCRS	−0.019^*** (0.001)	−0.014^*** (0.001)
GVRS	−0.042^*** (0.002)	−0.031^*** (0.002)
	M1 SIS ≤ 4 OR/95% CI	M3 SIS ≤ 4 OR/95% CI
FCRS	1.021^*** [1.016;1.026]	1.021^*** [1.015;1.026]
GVRS	1.052^*** [1.037;1.066]	1.048^*** [1.032;1.064]

Secondary Outcomes

	M1 SEVLT Recall β (se)	M3 SEVLT Recall β (se)
FCRS	−0.015^*** (0.001)	−0.012^*** (0.001)
GVRS	−0.031^*** (0.002)	−0.023^*** (0.002)
	M1 SEVLT Sum β (se)	M3 SEVLT Sum β (se)
FCRS	−0.016^*** (0.001)	−0.014^*** (0.001)
GVRS	−0.034^*** (0.002)	−0.025^*** (0.002)
	M1 WF β (se)	M3 WF β (se)
FCRS	−0.009^*** (0.001)	−0.006^*** (0.001)
GVRS	−0.021^*** (0.002)	−0.012^*** (0.002)
	M1 DSS β (se)	M3 DSS β (se)
FCRS	−0.017^*** (0.001)	−0.014^*** (0.001)
GVRS	−0.043^*** (0.002)	−0.034^*** (0.002)

FCRS, Framingham Cardiovascular Risk Score; GVRS, Global Vascular Risk Score.;

^***

p<0.001;

^**

p<0.01;

p<0.05;

Global Cognition (GC), Composite factor score; SIS, Six-item Screener; SEVLT, Spanish English verbal learning test; WF, word fluency; DSS, digit symbol substitution.; M1 = Crude; M2 = adjusted for education, Hispanic/Latino background, CESD-10, and study site adjustments.