Table 3.

Sex and age modifications in the associations between cardiovascular risk scores and cognitive function (z-scores for continuous outcomes). Results are derived from survey generalized linear models. Results for Hispanic/Latino adults ages 45–74 years without prevalent stroke or cardiovascular events (HCHS/SOL; 2008–2011)

	ΔSlope*	95% CI		p
		LL	UL
Sex modification
Female versus Male*
Contrasts
FCRS
Primary Outcomes
Global Cognition	0.009	0.006	0.013	0.000
SIS≤4	−0.002	−0.004	0.000	0.011
Secondary Outcomes
SEVLT-Recall	0.006	0.002	0.009	0.002
SEVLT-Sum	0.007	0.004	0.011	0.000
WF	0.005	0.002	0.009	0.003
DSS	0.009	0.006	0.012	0.000
GVRS
Primary Outcomes
Global Cognition	0.023	0.015	0.031	0.000
SIS≤4	−0.005	−0.008	−0.001	0.011
Secondary Outcomes
SEVLT-Recall	0.017	0.008	0.025	0.000
SEVLT-Sum	0.015	0.007	0.023	0.000
WF	0.012	0.004	0.020	0.005
DSS	0.023	0.015	0.031	0.000
Age modification
Age 45–64 versus 65+* Contrasts
FCRS
Primary Outcomes
Global Cognition	0.006	0.002	0.010	0.001
SIS≤4	0.000	−0.002	0.002	0.738
Secondary Outcomes
SEVLT-Recall	0.003	−0.001	0.007	0.109
SEVLT-Sum	0.003	0.000	0.007	0.063
WF	0.000	−0.005	0.004	0.889
DSS	0.009	0.006	0.013	<0.001
GVRS
Primary Outcomes
Global Cognition	0.021	0.011	0.031	<0.001
SIS≤4	−0.004	−0.009	0.001	0.091
Secondary Outcomes
SEVLT-Recall	0.016	0.007	0.026	0.001
SEVLT-Sum	0.013	0.002	0.023	0.015
WF	0.002	−0.009	0.014	0.681
DSS	0.028	0.019	0.036	<0.001

FCRS, Framingham Cardiovascular Risk Score; GVRS, Global Vascular Risk Score; Global Cognition, Composite factor score; SIS, Six-item Screener; SEVLT, Spanish English verbal learning test; WF, word fluency; DSS, digit symbol substitution; CI, confidence intervals (LL lower limit; and UL upper limit).; Models are adjusted for education, Hispanic/Latino background, CESD-10, and study site.;

^*Calculated group differences in slopes (Slope Males – Slope Females; Slope age 65+– Slope age 45–64 years) per 1% increase in cardiovascular risk score.