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. 2020 Jul 31;8:600. doi: 10.3389/fcell.2020.00600

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Copyright © 2020 Janna, Davarinejad, Joshi and Couture.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of DOT1L (A), COMPASS (B), and mPRC2 (C) Modes of Engagement with the Nucleosome. The nucleosome discs represent NCP structures captured in the same orientations. The side-by-side comparison shows surface representation of histones inside the nucleosome disc (gray) and cartoons depiction of DNA (gray) highlighting amino acids or DNA bases which come to close contact (≤5 Å) with residues of the associated enzyme or enzyme complex (red). Contact points involving histone tails were omitted due to lack of structural continuity.