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. 2020 Jul 10;21:737–750. doi: 10.1016/j.omtn.2020.07.007

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Injection of Exosomes from ADSCs Overexpressing SIRT1 Decreased AMI-Induced Myocardial Inflammation

(A) Macrophage density was assessed using Mac3 staining. Scale bars, 100 μm. (B) Quantification of infiltrated macrophages per area in frozen sections of infarcted hearts at days 3 and 7 after AMI surgery. ^#p < 0.05; ^##p < 0.01, compared with the AMI + vehicle group; ^&p < 0.05, compared with the AMI + ADSCs-Exos group; n = 6 per group. (C–E) The levels of TNF-α (C), IL-1β (D), and IL-10 (E) measured in heart homogenates after AMI or sham surgery for 24 h. ∗p < 0.05; ∗∗p < 0.01, versus the sham group; ^#p < 0.05, compared with the AMI + vehicle group; ^&p < 0.05, compared with the AMI + ADSCs-Exos group; n = 6 per group.