Table 2.
Correlation Analysis: Synovial fluid proteins identified by mass spectrometry across all RA and SpA samples correlating significantly (p-value < 0.05) to synovial fluid cfDNA
| UPID | Protein name | Gene name | R | p-value | NETs |
|---|---|---|---|---|---|
| P62805 | Histone H4 | HIST1H4A | 0.9170 | 1.52E−06 | + |
| P14780 | Matrix metalloproteinase-9 | MMP9 | 0.8141 | 4.02E−06 | + |
| P80188 | Neutrophil gelatinase-associated lipocalin | LCN2 | 0.7925 | 3.88E−08 | + |
| P07900 | Heat shock protein HSP 90-alpha | HSP90AA1 | 0.7314 | 4.40E−06 | |
| P37837 | Transaldolase | TALDO1 | 0.7292 | 7.12E−03 | |
| P02788 | Lactotransferrin | LTF | 0.7158 | 5.62E−10 | + |
| P20160 | Azurocidin | AZU1 | 0.7114 | 4.61E−05 | + |
| Q99880 | Histone H2B type 1-L | HIST1H2BL | 0.7008 | 1.61E−05 | + |
| P12814 | Alpha-actinin-1 | ACTN1 | 0.6964 | 3.86E−05 | + |
| P61626 | Lysozyme C | LYZ | 0.6946 | 1.57E−08 | + |
| P24158 | Myeloblastin | PRTN3 | 0.6803 | 4.89E−05 | + |
| P15153 | Ras-related C3 botulinum toxin substrate 2 | RAC2 | 0.6803 | 1.31E−04 | |
| P52566 | Rho GDP-dissociation inhibitor 2 | ARHGDIB | 0.6694 | 1.25E−03 | |
| P08246 | Neutrophil elastase | ELANE | 0.6660 | 1.35E−03 | + |
| P05164 | Myeloperoxidase | MPO | 0.6584 | 4.89E−07 | + |
| P52209 | 6-phosphogluconate dehydrogenase, decarboxylating | PGD | 0.6529 | 4.04E−04 | |
| P0DMV9 | Heat shock 70 kDa protein 1B | HSPA1B | 0.6524 | 1.35E−03 | |
| P63261 | Actin, cytoplasmic 2 | ACTG1 | 0.6419 | 1.28E−07 | |
| P00558 | Phosphoglycerate kinase 1 | PGK1 | 0.6270 | 3.28E−05 | |
| Q99878 | Histone H2A type 1-J | HIST1H2AJ | 0.6265 | 1.05E−03 | + |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | GAPDH | 0.6096 | 3.33E−06 | |
| P06744 | Glucose-6-phosphate isomerase | GPI | 0.6007 | 3.99E−03 | |
| P12429 | Annexin A3 | ANXA3 | 0.5955 | 2.14E−03 | |
| P08311 | Cathepsin G | CTSG | 0.5944 | 1.66E−04 | + |
| P06733 | Alpha-enolase | ENO1 | 0.5942 | 1.38E−06 | + |
| P14618 | Pyruvate kinase PKM | PKM | 0.5898 | 2.15E−06 | |
| P06702 | Protein S100-A9 | S100A9 | 0.5857 | 2.12E−06 | + |
| P07737 | Profilin-1 | PFN1 | 0.5778 | 5.90E−06 | |
| P08670 | Vimentin | VIM | 0.5745 | 1.58E−05 | |
| P60174 | Triosephosphate isomerase | TPI1 | 0.5720 | 4.09E−04 | |
| P13796 | Plastin-2 | LCP1 | 0.5704 | 5.45E−06 | + |
| Q01518 | Adenylyl cyclase-associated protein 1 | CAP1 | 0.5698 | 1.53E−04 | |
| P09211 | Glutathione S-transferase P | GSTP1 | 0.5578 | 1.67E−03 | |
| P00338 | l-Lactate dehydrogenase A chain | LDHA | 0.5531 | 4.14E−03 | |
| P04083 | Annexin A1 | ANXA1 | 0.5486 | 1.40E−04 | |
| P01033 | Metalloproteinase inhibitor 1 | TIMP1 | 0.5463 | 3.21E−04 | |
| P26038 | Moesin | MSN | 0.5314 | 4.19E−04 | |
| P62937 | Peptidyl-prolyl cis-trans isomerase A | PPIA | 0.5142 | 1.85E−04 | |
| P30740 | Leukocyte elastase inhibitor | SERPINB1 | 0.5103 | 4.34E−02 | |
| P18669 | Phosphoglycerate mutase 1 | PGAM1 | 0.5080 | 3.13E−04 | |
| Q71U36 | Tubulin alpha-1A chain | TUBA1A | 0.4917 | 1.07E−02 | |
| P22894 | Neutrophil collagenase | MMP8 | 0.4728 | 4.74E−03 | |
| P80511 | Protein S100-A12 | S100A12 | 0.4689 | 5.16E−03 | |
| P63104 | 14-3-3 protein zeta/delta | YWHAZ | 0.4675 | 2.70E−03 | |
| P29401 | Transketolase | TKT | 0.4575 | 1.58E−03 | |
| P09960 | Leukotriene A-4 hydrolase | LTA4H | 0.4572 | 3.91E−03 | |
| P23528 | Cofilin-1 | CFL1 | 0.4462 | 1.89E−03 | |
| P68133 | Actin, alpha skeletal muscle | ACTA1 | 0.4370 | 2.01E−02 | |
| P08133 | Annexin A6 | ANXA6 | 0.4199 | 7.79E−03 | |
| P02679 | Fibrinogen gamma chain | FGG | 0.4183 | 1.34E−03 | |
| P36222 | Chitinase-3-like protein 1 | CHI3L1 | 0.4106 | 7.67E−03 | |
| P12111 | Collagen alpha-3(VI) chain | COL6A3 | 0.3898 | 3.26E−03 | |
| P07195 | l-Lactate dehydrogenase B chain | LDHB | 0.3686 | 3.19E−02 | |
| P04075 | Fructose-bisphosphate aldolase A | ALDOA | 0.3684 | 2.94E−02 | |
| P02741 | C-reactive protein | CRP | 0.3470 | 8.78E−03 | |
| P04003 | C4b-binding protein alpha chain | C4BPA | 0.3119 | 2.17E−02 | |
| P02763 | Alpha-1-acid glycoprotein 1 | ORM1 | 0.3061 | 2.18E−02 | |
| P02750 | Leucine-rich alpha-2-glycoprotein | LRG1 | 0.3046 | 2.24E−02 | |
| P04040 | Catalase | CAT | 0.2955 | 2.70E−02 | |
| P07225 | Vitamin K-dependent protein S | PROS1 | 0.2941 | 2.78E−02 | |
| P08603 | Complement factor H | CFH | 0.2883 | 3.12E−02 | |
| P0DJI8 | Serum amyloid A-1 protein | SAA1 | 0.2866 | 3.56E−02 | |
| P60709 | Actin, cytoplasmic 1 | ACTB | 0.2793 | 4.09E−02 | |
| P49747 | Cartilage oligomeric matrix protein | COMP | − 0.2706 | 4.37E−02 | |
| P02751 | Fibronectin | FN1 | − 0.2939 | 2.79E−02 | |
| Q13790 | Apolipoprotein F | APOF | − 0.4627 | 3.02E−03 | |
| Q96RL7 | Vacuolar protein sorting-associated protein 13A | VPS13A | − 0.5619 | 1.23E−02 | |
| Q66K66 | Transmembrane protein 198 | TMEM198 | − 0.5646 | 2.27E−02 |