Table 4.
SF proteins identified by proteomics with statistically significant correlation (p-value < 0.05) to plasma CRP
| UPID | Protein name | Gene name | R | p value |
|---|---|---|---|---|
| P0DJI8 | Serum amyloid A-1 protein* | SAA1 | 0.7254 | 5.47E−10 |
| P02741 | C-reactive protein* | CRP | 0.7148 | 6.12E−10 |
| P02750 | Leucine-rich alpha-2-glycoprotein* | LRG1 | 0.5769 | 3.26E−06 |
| P02679 | Fibrinogen gamma chain* | FGG | 0.5399 | 1.75E−05 |
| Q7Z4H8 | KDEL motif-containing protein 2 | KDELC2 | 0.4856 | 4.82E−02 |
| P18428 | Lipopolysaccharide-binding protein | LBP | 0.4765 | 2.05E−04 |
| P07225 | Vitamin K-dependent protein S* | PROS1 | 0.4328 | 8.64E−04 |
| Q06033 | Inter-alpha-trypsin inhibitor heavy chain H3 | ITIH3 | 0.4321 | 9.85E−04 |
| P00751 | Complement factor B | CFB | 0.4182 | 1.34E−03 |
| P02671 | Fibrinogen alpha chain | FGA | 0.3954 | 2.56E−03 |
| P06702 | Protein S100-A9* | S100A9 | 0.3913 | 2.86E−03 |
| P02748 | Complement component C9 | C9 | 0.3893 | 3.02E−03 |
| P01011 | Alpha-1-antichymotrypsin | SERPINA3 | 0.3868 | 3.23E−03 |
| P01009 | Alpha-1-antitrypsin | SERPINA1 | 0.3865 | 3.26E−03 |
| P68133 | Actin, alpha skeletal muscle* | ACTA1 | 0.3791 | 4.66E−02 |
| P02743 | Serum amyloid P-component | APCS | 0.3657 | 6.03E−03 |
| P08603 | Complement factor H* | CFH | 0.3298 | 1.30E−02 |
| P36222 | Chitinase-3-like protein 1* | CHI3L1 | 0.3170 | 4.34E−02 |
| P02788 | Lactotransferrin* | LTF | 0.3042 | 2.26E−02 |
| P05156 | Complement factor I | CFI | 0.2866 | 3.23E−02 |
| P04003 | C4b-binding protein alpha chain* | C4BPA | 0.2727 | 4.60E−02 |
| Q14624 | Inter-alpha-trypsin inhibitor heavy chain H4 | ITIH4 | 0.2683 | 4.56E−02 |
| P27169 | Serum paraoxonase/arylesterase 1 | PON1 | − 0.2719 | 4.27E−02 |
| P02753 | Retinol-binding protein 4 | RBP4 | − 0.2900 | 3.02E−02 |
| P05452 | Tetranectin | CLEC3B | − 0.2923 | 2.88E−02 |
| P02656 | Apolipoprotein C-III | APOC3 | − 0.2934 | 2.82E−02 |
| Q92954 | Proteoglycan 4 | PRG4 | − 0.2970 | 2.62E−02 |
| P01871 | Ig mu chain C region | IGHM | − 0.2997 | 2.48E−02 |
| P19823 | Inter-alpha-trypsin inhibitor heavy chain H2 | ITIH2 | − 0.3006 | 2.44E−02 |
| P19827 | Inter-alpha-trypsin inhibitor heavy chain H1 | ITIH1 | − 0.3293 | 1.32E−02 |
| P02751 | Fibronectin* | FN1 | − 0.3301 | 1.30E−02 |
| P22352 | Glutathione peroxidase 3 | GPX3 | − 0.3325 | 2.74E−02 |
| P02647 | Apolipoprotein A-I | APOA1 | − 0.3343 | 1.18E−02 |
| P43652 | Afamin | AFM | − 0.3650 | 5.67E−03 |
| P02787 | Transferrin | TF | − 0.3669 | 5.41E−03 |
| P05154 | Plasma serine protease inhibitor | SERPINA5 | − 0.3706 | 9.51E−03 |
| P06396 | Gelsolin | GSN | − 0.3730 | 4.63E−03 |
| P02768 | Albumin | ALB | − 0.4892 | 1.30E−04 |
| Q96PD5 | N-Acetylmuramoyl-L-alanine amidase | PGLYRP2 | − 0.5021 | 8.06E−05 |
| P02766 | Transthyretin | TTR | − 0.5277 | 2.93E−05 |
| P29622 | Kallistatin | SERPINA4 | − 0.5492 | 1.17E−05 |
Proteins marked with * are also positive correlated to SF cfDNA