Fig. 5. PLS analysis for DEX uptake ratio at t = 1 min. Scree plot of PLS analysis with respect to number of components in the PLS regression and the RMSE of the prediction; curve inflection (elbow) indicated with an arrow (a). Loading plot of the first two PLS components describing the relationships between input parameters for the set of PBAEs tested (green) and the predicted DEX uptake ratio for the two end-capping agents (dark blue) (b).