Table 1.

Studies included in the meta-analysis, ordered by time of publication.

Study	Subjects RLS/controls	Seed Regions	Functional connectivity		IRLS
			Increase	Decrease
Ku et al.18	25/25	ventral posterior lateral nucleus of the thalamus	right parahippocampal gyrus, right precuneus, right precentral gyrus, left/right lingual gyrus	right superior temporal gyrus, left/right middle temporal gyrus, right medial frontal gyrus	26 ± 7
Gorges et al.19	26/26	motor/sensorimotor network	−	−	27 ± 6
		sensory thalamic network	left caudate nucleus, right putamen, left/right thalamus, right parahippocampal cortex,
		ventral attention network	left/right thalamus, right parahippocampal cortex
		dorsal attention network	right medial prefrontal cortex, right cingulate cortex, right supplementary eye field
		basal ganglia-thalamic network	left/right medial prefrontal cortex, left caudate nucleus, left putamen, left thalamus,
		cingulate network	left cingulate cortex
		brainstem network	−	−
Ku et al.20	16/16	default Mode Network	right superior parietal lobule, right supplementary motor area, left thalamus	left posterior cingulate cortex, right orbito-frontal gyrus, left precuneus, right subcallosal gyrus	26 ± 7
Ku et al.21	15/15	default mode network (morning)	Left/right thalamus, right superior parietal lobule	right medial frontal gyrus, left posterior cingulate, left precuneus, right subcallosal gyrus, right parahippocampal gyrus	26 ± 7
		default mode network (evening)	left declive, left cuneus, right middle occipital gyrus	right caudate tail, right caudate head, left anterior mid-cingulate gyrus, left caudate head
Liu et al.22	16/26	cuneus		left medial frontal gyrus/paracentral lobule	23 ± 6
		superior frontal gyrus	right medial prefrontal cortex
		thalamus	left cerebellum posterior lobe, right middle temporal gyrus
Li et al.23	20/18	right putamen		cingulate gyrus	23 ± 7
		left dorsal rostral putamen		left/right putamen, cingulate gyrus
		left dorsal caudal putamen		left putamen, left frontal pole, right superior frontal gyrus
		left ventral rostral putamen		left/right putamen, left frontal pole, right paracingulate gyrus
		right dorsal rostral putamen	right cerebellum	left putamen, right caudate, left frontal pole, right paracingulate gyrus
		right dorsal caudal putamen		left putamen
		right ventral rostral putamen		left caudate, right putamen, left superior cingulate gyrus
Lee et al.17	16/16	ventral posterior lateral nucleus of the thalamus	right temporal gyrus	left/right lingual gyrus	25 ± 8
Total	134/142

IRLS, international RLS rating scale ± standard deviation, RLS, restless legs syndrome.