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. 2020 Jul 31;11:1615. doi: 10.3389/fimmu.2020.01615

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Copyright © 2020 Tanimine, Ohira, Tahara, Ide, Tanaka, Onoe and Ohdan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism implicated in regulating anti-donor immune cells by LSECs in grafted liver. LSECs constitutively express classes I and II and have the capacity for Ag presentation. LSECs contribute to the establishment of immunological tolerance in grafted liver by promoting apoptosis of donor-MHC reactive T and B cells through Ag-presentation and PD-1/PD-L1 signaling.