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. Author manuscript; available in PMC: 2020 Dec 19.
Published in final edited form as: Science. 2020 Jun 19;368(6497):1335–1340. doi: 10.1126/science.aaz5143

Fig. 1. Epitopes of broadly neutralizing antibodies to the HA stem.

Fig. 1.

(A) The location of residues of interest in this study on the HA structures. All residues of interest are on HA2. One protomer of the trimer is shown in light gray and the other two protomers in dark gray and a detailed view of the location of the residues of interest is shown in the inset. (B-C) Epitopes of (B) CR9114 Fab in complex with H1 HA (PDB 4FQI) (26) and (C) FI6v3 in complex with H3 HA (PDB 3ZTJ) (27) are colored in yellow and green, and residues of interest colored in green. The arrows indicate the positions of HA2 residues 42 and 45, which are in the center of the bnAb epitopes. Antibody paratopes (CDRs and FR regions) are shown in tube representation and labeled accordingly. Blue: heavy chain. Pink: light chain. (D-E) The relative solvent accessibility (RSA) of each residue of interest is shown. Black bar: apo form. Gray bar: Fab-bound form.