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Binding affinity of IgGs and Fabs against HAs of WT and different H3/HK68 HA2 mutants.
| Kd in nM | WT | HA2-I45T | HA2-I45M | HA2-I45F | HA2-N49T |
|---|---|---|---|---|---|
| CR9114 Fab | 43.2 ± 0.4 | 779.6 ± 50.0 | 319.1 ± 12.1 | n.b. | 11.3 ± 0.4 |
| 27F3 Fab | 122.6 ± 3.0 | n.b. | n.b. | n.b. | 105.0 ± 1.0 |
| CR9114 IgG | < 0.1 | 164.8 ± 2.3 | 75.0 ± 1.0 | n.b. | < 0.1 |
| 27F3 IgG | 1.7 ± 0.1 | n.b. | n.b. | n.b. | 1.9 ± 0.9 |
| FI6v3 IgG | < 0.1 | 7.8 ± 0.2 | 6.7 ± 0.1 | 62.0 ± 0.2 | < 0.1 |
| S139/1 IgG | 2.1 ± 0.1 | 3.1 ± 0.3 | 1.9 ± 0.1 | 1.8 ± 0.1 | 2.8 ± 0.1 |
n.b.: no binding
