Figure 1.

Flowchart of miRNA–TF regulatory network analysis for CP in humans and mice. (A) Three lists of miRNAs, TFs and genes manually curated from literature in humans and mice. (B) Different types of interactions between TFs, miRNAs and genes. (C) Three types of regulatory motifs (type I, type II and type III). (D) The integrated miRNA–TF–gene regulatory network. (E) The hub gene selection, subnetwork identification and gene set enrichment analysis of network genes. (F) The consensus miRNAs/TFs/genes, subnetworks, motifs, pathways and GO terms shared between humans and mice.