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. 2020 Jul 31;11:1163. doi: 10.3389/fphar.2020.01163

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Copyright © 2020 Liu, Li, Zhang, Liu, Zhang, Hong, Wu, Zhang and Duan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The heart rate response of isoprenaline in Na_V1.8 knockout mice. (A) Scatter diagram of heart rate after isoprenaline application. (B) Line diagram of fold change of heart rate after isoprenaline treatment. Heart rate was normalized to the value of baseline heart rate for each group. WT, wild type; KO, knock out; NS, normal saline; IS, isoprenaline; BL, baseline.