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. 2020 Jul 31;8:714. doi: 10.3389/fcell.2020.00714

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Copyright © 2020 Jin, Li, Dong, Huang, Yu and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-181b-5p takes a part in the effects of cMTO1 on HSC activation. Primary 1-day-old HSCs were transduced with Ad-cMTO1 or Ad-cMTO1-Mut for 48 h and transfected with miR-181b-5p mimics for additional 48 h. (A) miR-181b-5p level in CCl₄ mice. (B) miR-181b-5p level in primary HSCs. (C) Reduced cell proliferation by cMTO1 over-expression was restored by miR-181b-5p. (D,E) cMTO1-suppressed α-SMA and Col1A1 were blocked down by miR-181b-5p. *P < 0.05 compared to the control. Each value is the mean ± SD of three experiments.