TABLE 3.
Gene ontology and pathway analyses of differentially expressed gene for the three largest clusters based on co-expression.
| Gene set name | P-value | Database | Cluster |
| Regulation of actin cytoskeleton | 1.03E-13 | KEGG | 1 |
| Pathways in cancer | 1.23E-13 | ||
| Axon guidance | 1.09E-12 | ||
| Focal adhesion | 4.96E-12 | ||
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 4.63E-09 | ||
| Fibrillar center | 1.13E-29 | GO Cellular | |
| Extracellular matrix | 8.57E-27 | ||
| Stress fiber | 1.24E-26 | ||
| Focal adhesion | 2.82E-23 | ||
| Actin cytoskeleton | 4.02E-22 | ||
| Actin binding | 3.66E-15 | GO Function | |
| Laminin binding | 2.37E-13 | ||
| Insulin-like growth factor binding | 9.72E-13 | ||
| Collagen binding | 3.73E-12 | ||
| Protein heterodimerization activity | 5.54E-12 | ||
| Cell migration involved in sprouting angiogenesis | 7.07E-18 | GO Processes | |
| Cell migration | 2.94E-16 | ||
| inactivation of MAPK activity | 3.31E-15 | ||
| Cytoskeleton organization | 6.34E-15 | ||
| Negative regulation of cell migration | 9.12E-15 | ||
| Cell-extracellular matrix interactions | 7.16E-15 | Reactome | |
| Signal transduction | 1.98E-13 | ||
| Non-integrin membrane-ECM interactions | 2.58E-12 | ||
| Signaling by Rho GTPases | 1.84E-11 | ||
| EPHA-mediated growth cone collapse | 2.30E-11 | ||
| RNA polymerase | 4.57E-13 | KEGG | 2 |
| Pyrimidine metabolism | 1.37E-12 | ||
| Alzheimer’s disease | 3.55E-11 | ||
| Purine metabolism | 4.11E-11 | ||
| GnRH signaling pathway | 1.84E-09 | ||
| Nucleolus | 5.96E-19 | GO Cellular | |
| Preribosome, large subunit precursor | 2.21E-18 | ||
| Small-subunit processome | 5.13E-18 | ||
| DNA-directed RNA polymerase III complex | 5.10E-15 | ||
| DNA-directed RNA polymerase I complex | 1.85E-14 | ||
| Pseudouridine synthase activity | 7.75E-16 | GO Function | |
| RNA binding | 1.25E-15 | ||
| snoRNA binding | 4.90E-14 | ||
| rRNA binding | 3.55E-13 | ||
| ATP-dependent RNA helicase activity | 5.23E-13 | ||
| RNA secondary structure unwinding | 1.57E-16 | GO Processes | |
| tRNA modification | 7.73E-16 | ||
| Positive regulation of gene expression, epigenetic | 3.09E-15 | ||
| Ribosomal large subunit biogenesis | 3.17E-15 | ||
| Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 3.32E-15 | ||
| rRNA modification in the nucleus and cytosol | 3.38E-18 | Reactome | |
| tRNA processing | 1.65E-17 | ||
| tRNA modification in the nucleus and cytosol | 1.66E-16 | ||
| rRNA processing | 9.91E-15 | ||
| tRNA processing in the nucleus | 1.69E-14 | ||
| RIG-I-like receptor signaling pathway | 1.24E-10 | KEGG | 3 |
| Cytosolic DNA-sensing pathway | 1.92E-07 | ||
| O-glycan biosynthesis | 1.163E-06 | ||
| Focal adhesion | 1.36893E-06 | ||
| Calcium signaling pathway | 2.06986E-05 | ||
| Caveola | 2.00E-08 | GO Cellular | |
| Proteinaceous extracellular matrix | 7.41E-08 | ||
| Postsynaptic membrane | 2.45E-06 | ||
| Microfibril | 4.99E-06 | ||
| Extracellular matrix | 1.12E-05 | ||
| Type I interferon receptor binding | 3.64E-07 | GO Function | |
| Neuropeptide binding | 5.89E-07 | ||
| Scavenger receptor activity | 6.23E-07 | ||
| Calcium-dependent phospholipid binding | 9.44E-07 | ||
| RNA binding | 2.46E-06 | ||
| Response to mechanical stimulus | 8.42E-09 | GO Processes | |
| Lung development | 1.55E-08 | ||
| Negative regulation of neuron apoptotic process | 5.29E-08 | ||
| Cellular response to hypoxia | 7.29E-08 | ||
| Regulation of type I interferon-mediated signaling pathway | 1.11E-07 | ||
| O-glycosylation of TSR domain-containing proteins | 3.73E-10 | Reactome | |
| Defective B3GALTL causes Peters plus syndrome (PpS) | 5.15E-10 | ||
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.29E-09 | ||
| O-linked glycosylation | 4.91E-08 | ||
| Diseases associated with O-glycosylation of proteins | 1.04E-07 |