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. 2020 Aug 6;10:13255. doi: 10.1038/s41598-020-69899-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of SFRP1 in DNA methylation interactive visualisation database. Five different profiles of information was shown in four kinds of cancer. (A,F,K,P) Gene expression of SFRP1 in RNA-sequencing read count. (B,G,L,Q) Differential methylation of the promoter region of SFRP1. (C,H,M,R) Scatter plots of promoter methylation and gene expression, analysed by Pearson’s method. (D,I,N,S) Spearman’s correlation analysis of promoter methylation and gene expression. (E,J,O,T) Kaplan–Meier progression-free survival curve by the degree of methylation of SFRP1. (A–E), gastric cancer; (F–J), colon cancer. (K–O), pancreatic cancer; (P–T), cholangiocarcinoma. SFRP1, secreted frizzled related protein 1.