Table II.
Sequences of epitope evaluated for binding to HLA-A*02:01 and recognition by T cells
| Gene (Residues) | Mutant/Nonmutant | Epitope | Mutation | HLA Restriction Element | No. of Cys Residues | Position of Mutation in Epitope | Position of Cys |
|---|---|---|---|---|---|---|---|
| CYFIP1016-124) | Mutant | SCSRAVPQV | 1121V | A*02:01 | 1 | 6 | 2 |
| CTAG2(157–165) | Nonmutant | SLLMWITQC | N/A | A*02:01 | 1 | N/A | 9 |
| TP53(168–176) | Mutant | HMTEVVRHC | R175H | A*02:01 | 1 | 8 | 9 |
| PMEL(639–647) | Nonmutant | RLPRIFCSC | N/A | A*02:01 | 2 | N/A | 7,9 |
| PHLPP1(563–571) | Mutant | ILCETCLIV | G566E | A*02:01 | 2 | 4 | 3,6 |
| HIVEP2(1674–1682) | Mutant | CISSCNPNL | P1682L | A*02:01 | 2 | 9 | 1, 5 |
| BING4(altemative. orf) | Nonmutant | CQWGRLWQL | N/A | A*02:01 | 1 | N/A | 1 |
| GnTV(intronic) | Nonmutant | VLPDVFIRC | N/A | A*02:01 | 1 | N/A | 9 |
| CDK4(23–32) | Mutant | ACDPHSGHFV | R23C | A*02:01 | 1 | 2 | 2 |
| TP53(241–249) | Mutant | SCMGGMNWR | R248W | A*68:01 | 1 | 8 | 2 |
| ECI2(350–358) | Mutant | CTIAVVNFL | N352I | A*68:02 | 1 | 3 | 1 |
| GALK1(242–250) | Mutant | qceevarvl | A249V | B* 35:03 | 1 | 8 | 2 |
| RSL1D1(175–183) | Mutant | KSPNPSTPC | R183C | C*01:02 | 1 | 9 | 9 |
N/A, not applicable.