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. 2020 Aug 6;10:13282. doi: 10.1038/s41598-020-69281-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The canonical pathway represented by differentially expressed proteins in the BALF between progressive and non-progressive sarcoidosis implementing Overlapping Canonical Pathway functionality in IPA. The 121 differentially expressed proteins map to twenty-seven canonical pathways. Each canonical pathway is represented as a node. The edges indicated at least two proteins between the nodes to indicate shared biological function. The Th1 pathway, CD28 signaling, CDC-42 signaling and IL-8 signaling are highly-connected nodes detected with this analysis.