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. 2020 Aug 6;10:13211. doi: 10.1038/s41598-020-70043-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) CD41 platelet immunohistochemistry of murine myocarditis 2 days after induction of myocarditis (× 20). Platelets were stained red. (B) Histological platelet count showed significant higher platelet numbers at early time points after induction of myocarditis compared to later time points. (C) Round golden LIBS-MPIOs bind to platelets in inflamed myocardium. They are highlighted with arrows. (D) Quantification of bound LIBS-MPIOs in the myocardium showed significant higher binding 2 days after induction of myocarditis compared to later time points. (E) Control antibody staining of murine myocarditis induced with CFA and porcine cardiac myosin (× 20). (F) CD41 immunohistochemistry of iCFA and myosin injected mice 2 days after injection. No relevant platelet accumulation was observed. (G) iCFA and myosin injected mice developed significantly less platelets accumulation in the myocardium at 2 days after injection compared to CFA and myosin injected mice. (H) Both control-MPIO injected myocarditis mice and LIBS-MPIO injected sham mice (iCFA + myosin) had significantly less MPIO accumulation in the myocardium compared to LIBS-MPIO injected myocarditis mice (CFA + myosin).