Table 10.

Clinically relevant drug interactions with antifungals[111][141][142][143][144]

Antifungal drug	Drug level is decreased by	Decreases level of these drugs	Increases level of these drugs
Griseofulvin	Phenobarbital	Anticoagulants, oral contraceptives, Cyclosporin	Potentiates action of alcohol-Disufiram like reaction
Terbinafine	Rifampicin	-	Anti-depressants beta blockers,
			Antiarrthymics class 1c, selective serotonin reuptake inhibitors.
			Caution when used with anticoagulants.
Itraconazole	H2 histamine blockers, proton pump inhibitors, rifampicin, rifabutin, INH, ritonavir, nevirapine, nortriptyline, carbamazepine, phenytoin, phenobarbital	Oral contraceptives	Glibenclamide, phenytoin, warfarin, cyclosporin, tacrolimus, digoxin, lovastatin, midazolam, triazolam, methylprednisolone, Saquinavir
Fluconazole	Rifampicin	Oral contraceptives	Sulfanylurea, nifedipine, theophylline, NSAID, warfarin, cyclosporine