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. 2020 Aug 7;15(8):e0237141. doi: 10.1371/journal.pone.0237141

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© 2020 Soe et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 7 — i) Hierarchical complete linkage clustered heat map of 500 metabolites met the requirement of FC > 2.0 and p < 0.05. Clustering based on individual samples (A) and categories (B) revealed the similarity as well as the differential metabolic expression in HC/DWOWS and DWWS/SD. ii) Volcano plot comparing p value against fold change of (A) DWOWS, (B) DWWS and (C) SD as compared to HC, and the top regulated metabolites in each category. A higher number of metabolites were up-regulated in dengue patients from all three categories compared to down-regulated metabolites. iii) Venn diagrams of (A) up-regulated and (B) down-regulated metabolites in DWOWS, DWWS and SD as compared to HC, and the top regulated metabolites in each category. DWOWS, DWWS and SD shared high commonality in the up-regulated metabolites, however, no metabolite was commonly down-regulated in all the categories.