Table 3.

Neutrophil to lymphocyte ratio (NLR) and breast cancer risk by breast cancer subtypes and menopausal status.

	Cases/Controls	ORa	95% CI	ORb	95% CI
By breast cancer subtypes:
Luminal A
< 1.26	30/117	1.0		1.0
1.26–1.85	61/121	1.91	1.16–3.20	1.76	1.03–3.05
> 1.85	74/117	2.34	1.43–3.90	2.00	1.17–3.45
P-trend			< 0.001		< 0.001
Luminal B
< 1.26	7/117	1.0		1.0
1.26–1.85	11/121	1.32	0.48–3.78	1.10	0.39–3.24
> 1.85	18/117	2.02	0.81–5.50	1.83	0.70–5.15
P-trend			0.049		0.08
TNBC
< 1.26	12/117	1.0		1.0
1.26–1.85	8/121	0.62	0.23–1.57	0.59	0.22–1.54
> 1.85	19/117	1.46	0.68–3.25	1.56	0.70–3.59
P-trend			0.03		0.03
HER2-overexpressed
< 1.26	3/117	1.0		1.0
1.26–1.85	13/121	3.91	1.21–17.48	3.63	1.10–16.45
> 1.85	6/117	1.76	0.45–8.57	1.80	0.45–8.90
P-trend			0.77		0.79
By HER2 status:
HER2-negative
< 1.26	42/117	1.0		1.0
1.26–1.85	70/121	1.58	0.99–2.51	1.42	0.88–2.33
> 1.85	96/117	2.15	1.38–3.39	1.87	1.16–3.02
P-trend			< 0.001		< 0.001
HER2-positive
< 1.26	10/117	1.0		1.0
1.26–1.85	25/121	2.22	1.02–5.14	2.02	0.92–4.75
> 1.85	23/117	1.88	0.85–4.39	1.79	0.79–4.28
P-trend			0.14		0.18
By menopausal status:
Premenopausal
< 1.26	18/19	1.0		1.0
1.26–1.85	37/26	1.43	0.60–3.43	1.31	0.52.3.32
> 1.85	63/36	1.76	0.79–3.98	1.65	0.69–3.92
P-trend			0.10		0.19
Postmenopausal
< 1.26	40/98	1.0		1.0
1.26–1.85	64/95	1.66	1.01–2.74	1.62	0.97–2.73
> 1.85	76/81	2.32	1.42–3.83	2.06	1.23–3.50
P-trend			< 0.001		< 0.001

^aAdjusted for age at diagnosis (cases) and age at interview (controls).

^bFurther adjusted for age at menarche, parity, menopausal status, and BMI.