Table 3. Association estimates between sUmod and renin and aldosterone.

	Renin	P value	Aldosterone	P value
Without adjustment
Total study group	-0.14 ± 0.03	< 0.001	0.01 ± 0.10	0.857
No arterial hypertension	-0.08 ± 0.04	0.072	0.05 ± 0.05	0.332
Arterial hypertension	-0.13 ± 0.04	0.002	-0.02 ± 0.04	0.547
Model 1: Adjustment for sex and age
Total study group	-0.10 ± 0.03	0.001	-0.02 ± 0.03	0.498
No arterial hypertension	-0.05 ± 0.04	0.261	0.04 ± 0.05	0.476
Arterial hypertension	-0.01 ± 0.04	0.024	-0.05 ± 0.04	0.176
Model 2: Adjustment for sex, age and eGFR
Total study group	-0.05 ± 0.03	0.088	0.01 ± 0.03	0.699
No arterial hypertension	-0.04 ± 0.04	0.355	0.05 ± 0.05	0.375
Arterial hypertension	-0.04 ± 0.04	0.403	-0.01 ± 0.04	0.713
Model 5: Adjustment for sex, age, eGFR, BMI, fasting glucose, smoking, previous stroke and myocardial infarction, use of beta-blockers, angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists (and arterial hypertension in the total study group)
Total study group	0.02 ± 0.04	0.566	-0.02 ± 0.04	0.695
No arterial hypertension	-0.01 ± 0.04	0.895	0.08 ± 0.06	0.135
Arterial hypertension	0.01 ± 0.03	0.777	0.02 ± 0.04	0.456

β coefficient ± standard error from linear regression models are given per standard deviation sUmod. n = 1097 (total study group), 409 (without arterial hypertension), 688 (with arterial hypertension).