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. 2020 Jul 12;105(9):e3207–e3223. doi: 10.1210/clinem/dgaa449

Table 2.

Comparisons of the Relative Abundance of 24 Tumor-Infiltrating Immune Cells (TIICs) Among the Three Immune Clusters of Pituitary Adenomas

TIICs (%) Cluster 1 (n = 46) Cluster 2 (n = 55) Cluster 3 (n = 39) P (total) P (1, 2) P (1, 3) P (2, 3)
B cells 5.87 ± 2.41 2.66 ± 1.84 4.14 ± 2.56 <0.001 <0.001 0.006 0.009
CD4 + T cells 3.90 ± 1.97 8.78 ± 3.56 5.60 ± 3.84 <0.001 <0.001 0.017 <0.001
CD8 + T cells 4.96 ± 2.15 2.28 ± 1.33 2.23 ± 1.76 <0.001 <0.001 <0.001 0.998
Naïve CD4 + T cells 3.33 ± 2.55 0.81 ± 1.71 4.86 ± 4.01 <0.001 <0.001 0.013 <0.001
Naïve CD8 + T cells 2.99 ± 2.07 1.05 ± 1.61 2.80 ± 2.11 <0.001 <0.001 0.651 <0.001
Cytotoxic T cells 4.09 ± 2.66 5.69 ± 2.59 2.02 ± 3.60 <0.001 0.007 0.001 <0.001
Exhausted T cells 0.52 ± 0.99 0.32 ± 0.83 0.36 ± 0.10 0.516 0.267 0.418 0.827
T cells regulatory 1 2.77 ± 2.58 14.22 ± 2.48 2.56 ± 2.29 <0.001 <0.001 0.740 <0.001
Natural regulatory T cells 4.64 ± 2.64 3.99 ± 2.49 1.84 ± 1.81 <0.001 0.214 <0.001 <0.001
Induced regulatory T cells 2.93 ± 3.06 3.54 ± 3.13 3.73 ± 3.54 0.479 0.345 0.258 0.784
T-helper 1 cells 2.54 ± 2.47 6.41 ± 3.30 4.77 ± 3.24 <0.001 <0.001 0.001 0.011
T-helper 2 cells 2.71 ± 2.60 4.30 ± 1.87 0.56 ± 0.10 <0.001 0.008 <0.001 <0.001
T-helper 17 cells 7.02 ± 4.82 7.34 ± 2.51 4.19 ± 4.04 <0.001 0.688 0.001 <0.001
Follicular T-helper cells 1.69 ± 1.40 4.00 ± 2.05 3.74 ± 3.70 <0.001 <0.001 0.001 0.660
Central memory T cells 4.96 ± 2.78 0.32 ± 0.86 3.67 ± 2.92 <0.001 <0.001 0.010 <0.001
Effector memory T cells 0.41 ± 0.96 1.53 ± 1.18 2.68 ± 2.53 <0.001 0.001 <0.001 0.001
Mucosal-associated invariant T cells 8.85 ± 4.04 2.16 ± 2.38 3.45 ± 3.69 <0.001 <0.001 <0.001 0.069
Natural killer T cells 1.89 ± 2.22 3.69 ± 2.28 4.38 ± 3.25 <0.001 0.001 <0.001 0.204
Gamma delta T cells 2.48 ± 1.87 2.89 ± 2.15 1.93 ± 2.11 0.091 0.325 0.226 0.079
Dendritic cells 3.62 ± 2.10 5.79 ± 2.35 13.03 ± 6.37 <0.001 0.006 <0.001 <0.001
Monocytes 13.52 ± 3.57 4.81 ± 2.88 3.68 ± 2.71 <0.001 <0.001 <0.001 0.084
Macrophages 5.23 ± 2.61 2.86 ± 1.53 10.01 ± 6.51 <0.001 0.002 <0.001 <0.001
Natural killer cells 4.50 ± 2.90 6.74 ± 2.03 6.16 ± 3.54 <0.001 <0.001 0.007 0.329
Neutrophils 4.64 ± 3.98 3.85 ± 3.36 7.62 ± 3.37 <0.001 0.269 <0.001 <0.001

P value (total) refers to the variation among the 3 clusters. P (1, 2) indicates the variation between clusters 1 and 2. P (1, 3) shows the variation between clusters 1 and 3. P (2, 3) indicates the variation between clusters 2 and 3.

Abbreviation: TIIC, tumor-infiltrating immune cell.