Table 2.
Comparisons of the Relative Abundance of 24 Tumor-Infiltrating Immune Cells (TIICs) Among the Three Immune Clusters of Pituitary Adenomas
TIICs (%) | Cluster 1 (n = 46) | Cluster 2 (n = 55) | Cluster 3 (n = 39) | P (total) | P (1, 2) | P (1, 3) | P (2, 3) |
---|---|---|---|---|---|---|---|
B cells | 5.87 ± 2.41 | 2.66 ± 1.84 | 4.14 ± 2.56 | <0.001 | <0.001 | 0.006 | 0.009 |
CD4 + T cells | 3.90 ± 1.97 | 8.78 ± 3.56 | 5.60 ± 3.84 | <0.001 | <0.001 | 0.017 | <0.001 |
CD8 + T cells | 4.96 ± 2.15 | 2.28 ± 1.33 | 2.23 ± 1.76 | <0.001 | <0.001 | <0.001 | 0.998 |
Naïve CD4 + T cells | 3.33 ± 2.55 | 0.81 ± 1.71 | 4.86 ± 4.01 | <0.001 | <0.001 | 0.013 | <0.001 |
Naïve CD8 + T cells | 2.99 ± 2.07 | 1.05 ± 1.61 | 2.80 ± 2.11 | <0.001 | <0.001 | 0.651 | <0.001 |
Cytotoxic T cells | 4.09 ± 2.66 | 5.69 ± 2.59 | 2.02 ± 3.60 | <0.001 | 0.007 | 0.001 | <0.001 |
Exhausted T cells | 0.52 ± 0.99 | 0.32 ± 0.83 | 0.36 ± 0.10 | 0.516 | 0.267 | 0.418 | 0.827 |
T cells regulatory 1 | 2.77 ± 2.58 | 14.22 ± 2.48 | 2.56 ± 2.29 | <0.001 | <0.001 | 0.740 | <0.001 |
Natural regulatory T cells | 4.64 ± 2.64 | 3.99 ± 2.49 | 1.84 ± 1.81 | <0.001 | 0.214 | <0.001 | <0.001 |
Induced regulatory T cells | 2.93 ± 3.06 | 3.54 ± 3.13 | 3.73 ± 3.54 | 0.479 | 0.345 | 0.258 | 0.784 |
T-helper 1 cells | 2.54 ± 2.47 | 6.41 ± 3.30 | 4.77 ± 3.24 | <0.001 | <0.001 | 0.001 | 0.011 |
T-helper 2 cells | 2.71 ± 2.60 | 4.30 ± 1.87 | 0.56 ± 0.10 | <0.001 | 0.008 | <0.001 | <0.001 |
T-helper 17 cells | 7.02 ± 4.82 | 7.34 ± 2.51 | 4.19 ± 4.04 | <0.001 | 0.688 | 0.001 | <0.001 |
Follicular T-helper cells | 1.69 ± 1.40 | 4.00 ± 2.05 | 3.74 ± 3.70 | <0.001 | <0.001 | 0.001 | 0.660 |
Central memory T cells | 4.96 ± 2.78 | 0.32 ± 0.86 | 3.67 ± 2.92 | <0.001 | <0.001 | 0.010 | <0.001 |
Effector memory T cells | 0.41 ± 0.96 | 1.53 ± 1.18 | 2.68 ± 2.53 | <0.001 | 0.001 | <0.001 | 0.001 |
Mucosal-associated invariant T cells | 8.85 ± 4.04 | 2.16 ± 2.38 | 3.45 ± 3.69 | <0.001 | <0.001 | <0.001 | 0.069 |
Natural killer T cells | 1.89 ± 2.22 | 3.69 ± 2.28 | 4.38 ± 3.25 | <0.001 | 0.001 | <0.001 | 0.204 |
Gamma delta T cells | 2.48 ± 1.87 | 2.89 ± 2.15 | 1.93 ± 2.11 | 0.091 | 0.325 | 0.226 | 0.079 |
Dendritic cells | 3.62 ± 2.10 | 5.79 ± 2.35 | 13.03 ± 6.37 | <0.001 | 0.006 | <0.001 | <0.001 |
Monocytes | 13.52 ± 3.57 | 4.81 ± 2.88 | 3.68 ± 2.71 | <0.001 | <0.001 | <0.001 | 0.084 |
Macrophages | 5.23 ± 2.61 | 2.86 ± 1.53 | 10.01 ± 6.51 | <0.001 | 0.002 | <0.001 | <0.001 |
Natural killer cells | 4.50 ± 2.90 | 6.74 ± 2.03 | 6.16 ± 3.54 | <0.001 | <0.001 | 0.007 | 0.329 |
Neutrophils | 4.64 ± 3.98 | 3.85 ± 3.36 | 7.62 ± 3.37 | <0.001 | 0.269 | <0.001 | <0.001 |
P value (total) refers to the variation among the 3 clusters. P (1, 2) indicates the variation between clusters 1 and 2. P (1, 3) shows the variation between clusters 1 and 3. P (2, 3) indicates the variation between clusters 2 and 3.
Abbreviation: TIIC, tumor-infiltrating immune cell.