Table 2.

Comparisons of the Relative Abundance of 24 Tumor-Infiltrating Immune Cells (TIICs) Among the Three Immune Clusters of Pituitary Adenomas

TIICs (%)	Cluster 1 (n = 46)	Cluster 2 (n = 55)	Cluster 3 (n = 39)	P (total)	P (1, 2)	P (1, 3)	P (2, 3)
B cells	5.87 ± 2.41	2.66 ± 1.84	4.14 ± 2.56	<0.001	<0.001	0.006	0.009
CD4 + T cells	3.90 ± 1.97	8.78 ± 3.56	5.60 ± 3.84	<0.001	<0.001	0.017	<0.001
CD8 + T cells	4.96 ± 2.15	2.28 ± 1.33	2.23 ± 1.76	<0.001	<0.001	<0.001	0.998
Naïve CD4 + T cells	3.33 ± 2.55	0.81 ± 1.71	4.86 ± 4.01	<0.001	<0.001	0.013	<0.001
Naïve CD8 + T cells	2.99 ± 2.07	1.05 ± 1.61	2.80 ± 2.11	<0.001	<0.001	0.651	<0.001
Cytotoxic T cells	4.09 ± 2.66	5.69 ± 2.59	2.02 ± 3.60	<0.001	0.007	0.001	<0.001
Exhausted T cells	0.52 ± 0.99	0.32 ± 0.83	0.36 ± 0.10	0.516	0.267	0.418	0.827
T cells regulatory 1	2.77 ± 2.58	14.22 ± 2.48	2.56 ± 2.29	<0.001	<0.001	0.740	<0.001
Natural regulatory T cells	4.64 ± 2.64	3.99 ± 2.49	1.84 ± 1.81	<0.001	0.214	<0.001	<0.001
Induced regulatory T cells	2.93 ± 3.06	3.54 ± 3.13	3.73 ± 3.54	0.479	0.345	0.258	0.784
T-helper 1 cells	2.54 ± 2.47	6.41 ± 3.30	4.77 ± 3.24	<0.001	<0.001	0.001	0.011
T-helper 2 cells	2.71 ± 2.60	4.30 ± 1.87	0.56 ± 0.10	<0.001	0.008	<0.001	<0.001
T-helper 17 cells	7.02 ± 4.82	7.34 ± 2.51	4.19 ± 4.04	<0.001	0.688	0.001	<0.001
Follicular T-helper cells	1.69 ± 1.40	4.00 ± 2.05	3.74 ± 3.70	<0.001	<0.001	0.001	0.660
Central memory T cells	4.96 ± 2.78	0.32 ± 0.86	3.67 ± 2.92	<0.001	<0.001	0.010	<0.001
Effector memory T cells	0.41 ± 0.96	1.53 ± 1.18	2.68 ± 2.53	<0.001	0.001	<0.001	0.001
Mucosal-associated invariant T cells	8.85 ± 4.04	2.16 ± 2.38	3.45 ± 3.69	<0.001	<0.001	<0.001	0.069
Natural killer T cells	1.89 ± 2.22	3.69 ± 2.28	4.38 ± 3.25	<0.001	0.001	<0.001	0.204
Gamma delta T cells	2.48 ± 1.87	2.89 ± 2.15	1.93 ± 2.11	0.091	0.325	0.226	0.079
Dendritic cells	3.62 ± 2.10	5.79 ± 2.35	13.03 ± 6.37	<0.001	0.006	<0.001	<0.001
Monocytes	13.52 ± 3.57	4.81 ± 2.88	3.68 ± 2.71	<0.001	<0.001	<0.001	0.084
Macrophages	5.23 ± 2.61	2.86 ± 1.53	10.01 ± 6.51	<0.001	0.002	<0.001	<0.001
Natural killer cells	4.50 ± 2.90	6.74 ± 2.03	6.16 ± 3.54	<0.001	<0.001	0.007	0.329
Neutrophils	4.64 ± 3.98	3.85 ± 3.36	7.62 ± 3.37	<0.001	0.269	<0.001	<0.001

P value (total) refers to the variation among the 3 clusters. P (1, 2) indicates the variation between clusters 1 and 2. P (1, 3) shows the variation between clusters 1 and 3. P (2, 3) indicates the variation between clusters 2 and 3.

Abbreviation: TIIC, tumor-infiltrating immune cell.