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. 2020 Jul 21;6(4):e484. doi: 10.1212/NXG.0000000000000484

Figure 3. qDMPK expression and splicing analysis.

Figure 3

Data are mean ± SD. (A) qDMPK expression in patients with DM1 vs controls. (B) Percentage of the DM1 spliced-related isoform in patients with DM1 compared with controls for MBNL1, IR, and ATP2A1 transcripts measured with RT-PCR. MBNL1 and ATP2A1 showed no significant differences, whereas IR showed a tendency of higher expression in controls compared with patients (p = 0.057; effect size [Cohen d] = 1.83). DMPK = dystrophia myotonica protein; IR = insulin receptor; MNBL1 = muscleblind like 1.