Table 1.
Pharmacokinetic Parameters for VCAMelid, BiVCAMelid, and VCAM/ALB8
| Parametera | VCAMelid | BiVCAMelid | VCAM/ALB8 |
|---|---|---|---|
| AUCinf (%ID/g h) | 9.56 (1.40)### | 19.8 (7.6)### | 389 (40) |
| CL (mL/h) | 10.6 (1.6)*,## | 5.79 (2.87)# | 0.259 (0.025) |
| t1/2,β (h) | 1.59 (0.17)### | 1.97 (0.05)### | 13.2 (2.8) |
| Vss (mL) | 16.9 (7.0) | 7.87 (0.48) | 9.00 (0.21) |
a
Parameters are displayed as Mean (SEM). Comparisons were made using one-way ANOVA with Tukey’s post-hoc test
*
(p < 0.05)
**
(p < 0.01)
***
(p < 0.001) vs BiVCAMelid
#
(p < 0.05)
##
(p < 0.01)
###
(p < 0.001) vs VCAM/ALB8.