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. 2020 Jun 23;7(5):e805. doi: 10.1212/NXI.0000000000000805

Figure 2. ROC curves, exploratory data analysis for selected parameters, and sample fovea.

Figure 2

ROC curves for best-performing foveal shape and standard OCT parameters discriminating between (A) NMOSD vs MS, (B) NMOSD ON− vs MS ON−, and (C) NMOSD ON + vs MS ON+. Box and dot plots for (D) pit flat disk area, (E) average pit flat disk diameter, (F) inner rim volume, and (G) major slope disk length, the selected 4 foveal shape parameters. (H) Rim volume and (I) average pit depth, as example foveal shape parameters affected by ON but not diagnosis. A sample central (foveal) B scan of (J) MS ON− and (K) NMOSD ON−, chosen from the median of the selected pit flat disk parameters in each group, demonstrating the difference in foveal pit (pit flat disk), between NMOSD and MS in eyes without a history of ON. AUC = area under the curve; FT = foveal thickness; pRNFL = peripapillary retinal nerve fiber layer thickness; INL = inner nuclear layer volume; HC = healthy controls; MS = patients with MS; NMOSD = patients with neuromyelitis optica spectrum disorders; ON = optic neuritis; ON− = eyes without a history of ON; ON+ = eyes with a history of ON; ROC = receiver operating characteristic.