Table 2.
Laboratory Data Findings of the Study Subjects
| KPT2D | T1D | P | P Adjusted | |
|---|---|---|---|---|
| Glucose | ||||
| Fasting glucose (mmol/L) | 13.3 ± 0.3 | 13.0 ± 0.8 | 0.93 | 0.90 |
| 2 h glucose (mmol/L) | 19.7 ± 0.5 | 18.4 ± 0.9 | 0.19 | 0.08 |
| Fasting C-peptide (nmol/L) | 0.66 ± 0.03 | 0.12 ± 0.02 | <0.0001 | <0.0001 |
| 2 h C-peptide (nmol/L) | 1.02 ± 0.06 | 0.19 ± 0.06 | <0.0001 | <0.0001 |
| Hemoglobin A1c (%) | 11.8 ± 0.3 | 12.7 ± 0.4 | 0.03 | 0.08 |
| Acidosis | ||||
| Ketoacidosis proportion (n, %) | 57, 30% | 62, 54% | <0.0001 | <0.0001 |
| PH | 7.20 ± 0.02 | 7.12 ± 0.02 | 0.005 | 0.011 |
| HCO3 (mmol/L) | 11.7 ± 0.5 | 8.2 ± 0.5 | 0.039 | 0.049 |
| Lipids | ||||
| Total cholesterol (mmol/L) | 4.8 ± 0.2 | 4.0 ± 0.2 | 0.01 | 0.005 |
| Triglyceride (mmol/L) | 3.9 ± 0.3 | 1.0 ± 0.3 | <0.0001 | 0.002 |
| HDL-cholesterol (mmol/L) | 1.07 ± 0.04 | 1.39 ± 0.05 | 0.005 | 0.02 |
| LDL-cholesterol (mmol/L) | 2.69 ± 0.10 | 2.59 ± 0.17 | 0.67 | 0.13 |
| Liver enzymes | ||||
| Alanine aminotransferase (U/L) | 63.5 ± 5.0 | 18.75 ± 6.3 | 0.0001 | 0.0004 |
| Aspartate aminotransferase (U/L) | 46.8 ± 5.7 | 23.9 ± 6.8 | 0.013 | 0.04 |
| Renal function | ||||
| Serum creatinine (μmol/L) | 83.7 ± 3.5 | 86.9 ± 3.6 | 0.38 | 0.81 |
| Serum uric acid (μmol/L) | 377 ± 14 | 210 ± 16 | <0.0001 | 0.001 |
| eGFR (mL/min/1.73m2) | 105 ± 0.5 | 103 ± 0.5 | 0.76 | 0.77 |
Notes: Data are presented with means ± SEM or %; P, KPT2D versus T1D; P adjusted, KPT2D versus T1D adjusted by gender.
Abbreviations: KPT2D, ketosis-prone type 2 diabetes; T1D, type 1 diabetes with ketosis.