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. 2020 Jul 2;107(2):330–341. doi: 10.1016/j.ajhg.2020.06.004

Figure 3.

Figure 3

TEM Analyses of Sperm Cells from Men Harboring Bi-allelic DNAH8 Variants

(A and B) Cross-sections of the mid-piece (A) and principal piece (B) of the sperm flagella in a control individual show the typical ‘‘9 + 2’’ microtubule structure, including nine pairs of peripheral microtubule doublets (DMT; blue arrows), nine outer dense fibers (ODF; yellow arrows), and the central pair of microtubules (CP; red arrows). The outer dynein arms (ODA; green arrows) and inner dynein arms (IDA; pink arrows) are also visible. Scale bars: 200 μm.

(C–F) In the spermatozoa from men harboring bi-allelic DNAH8 variants, various axonemal anomalies can be observed, including the lack of CP (C) or DMT (D). Misarranged (D) or supernumerary ODFs (E) were also observed. ODAs were disassembled or absent in the samples from men carrying bi-allelic DNAH8 variants (C–F).