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. 2020 Apr 29;69(9):1823–1832. doi: 10.1007/s00262-020-02587-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Comparative analysis of the pretreatment tumor immune signatures between patient 1 and patient 2. a Tumor mutational burden. b RNA expression of various proteins playing a role in T cell signaling, differentiation, exhaustion, and cytotoxicity. Expression levels of chemokines, immunosuppressive enzymes, and β2M as well as of MHC class I and MHC class II were also analyzed. Transcripts per million base pairs were used to compare gene expression levels between the two patients. c Density of CD8+ TILs as determined by IHC in pretreatment tumor tissue. Mb Megabase