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. 2020 Apr 24;69(9):1713–1724. doi: 10.1007/s00262-020-02566-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The immune correlative studies and NGS of the enrolled patients. (a) Dynamic changes of serum IL-6 and lymphocytes subsets of patients with paired test results during the first combined CATAP treatment of the combined stage. (b) Changes of serum IL-6 and lymphocytes subsets of patients with paired test results before and 3 weeks after the first combined CATAP treatment of the combined stage. (c) Tumor mutation burden of responders and non-responders. (d) Heatmap of genetic alterations in pretreatment tumors of responding and non-responding patients. Melanoma signature genes, PD-1 blockade-associated genes that found mutated in our cohort and mutated genes occurred in more than 25% in non-responding patients while absent in the responding group were displayed