Table 1.
Summary Information of the 12 Phenotypes in UK Biobank Data Analysis
| Phenotype | PheCode | # of Events (Affected Individual) | Event Rate | Mean (SD) of Age at Event | # of Significant Locia |
|---|---|---|---|---|---|
| Essential hypertension | 401.1 | 76,566 | 27.09% | 62.7 (7.67) | 204 (23) |
| Abdominal hernia | 550 | 45,957 | 16.26% | 59.88 (9) | 45 (0) |
| Hyperlipidemia | 272.1 | 35,623 | 12.60% | 63.4 (7.52) | 70 (1) |
| Osteoarthrosis | 740 | 29,071 | 10.29% | 62.88 (7.96) | 22 (5) |
| Cardiac dysrhythmias | 427 | 25,585 | 9.05% | 63.08 (8.58) | 29 (1) |
| Asthma | 495 | 25,240 | 8.93% | 58.33 (9.74) | 74 (2) |
| Cataract | 366 | 22,635 | 8.01% | 65.94 (7.3) | 24 (2) |
| Coronary atherosclerosis | 411.4 | 19,079 | 6.75% | 62.38 (7.41) | 69 (2) |
| Type 2 diabetes | 250.2 | 18,557 | 6.57% | 62.76 (7.91) | 70 (2) |
| Parkinson disease | 332 | 1,345 | 0.48% | 66.7 (7.08) | 1 (0) |
| Alzheimer disease | 290.11 | 641 | 0.23% | 70.53 (5.09) | 2 (0) |
| Schizophrenia | 295.1 | 551 | 0.19% | 65.26 (8.24) | 1 (0) |
a
Number of significant loci based on the SPACox method (and number of not significant loci based on SPACC). Using significance level 510-8, we identified a total of 611 loci with a SPACox p value < 5 × 10-8, of which, 38 loci did not reach genome-wide significance in SPACC (p value > 5 × 10-8). We clustered variants within the 200 kb region or at the same gene region as one locus.