Table 3.
Levels of the peripheral blood markers by irAE development
| Blood parameter | irAEs, n (%) | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| OR (95%CI) | p value | OR (95%CI) | p value | ||
| L-NLR (n = 44) | 32 (72.7) | 0.051(0.02–0.14) | <0.001 | 0.04 (0.01–0.13) | <0.001 |
| H-NLR (n = 58) | 7 (12.1) | 1 | 1 | ||
| L-LDH (n = 33) | 15 (45.5%) | 0.64(0.28–1.49) | 0.301 | 0.45 (0.14–1.41) | 0.169 |
| H-LDH (n = 69) | 24 (34.8%) | 1 | 1 | ||
| H-PNI (n = 55) | 30 (54.5%) | 5.07(2.06–12.4) | <0.001 | 7.61 (2.20–26.3) | 0.001 |
| L-PNI (n = 47) | 9 (19.1%) | 1 | 1 | ||
OR odds ratio, CI confidence interval, H-NLR high NLR, H-LDH high LDH, H-PNI high PNI, irAEs immune-related adverse events, NLR neutrophil-to-lymphocyte ratio, LDH lactate dehydrogenase, PNI prognostic nutrition index, L-NLR low NLR, L-LDH low LDH, L-PNI low PNI