Table 2.
Morphological features in various thyroid tumors
| Morphologic feature | HTT | PTC | MTC | NIFTP |
|---|---|---|---|---|
| Circumscribed nodule | + | −/+ | +/− | + |
| Trabecular pattern | + | − | +/− | − |
| Spindle nuclei | + | − | +/− | − |
| Nuclear pseudoinclusions | + | + | +/− | + |
| Nuclear grooves | + | + | Rare | + |
| Hyaline material | + | − | + | − |
| Amyloid material | − | − | + | − |
| Cytoplasmic yellow bodies | + | − | − | − |
| Psammoma bodies | +/− | + | −/+ | − |
| MIB-1a | + | − | − | − |
| Cytokeratin-19 | − | + | − | +/− |
| Galectin-3 | −/+ | + | + | +/− |
HTT hyalinizing trabecular tumor, PTC papillary thyroid carcinoma, NIFTP non-invasive follicular thyroid neoplasm with papillary-like nuclear features, MTC medullary thyroid carcinoma
aMembranous and cytoplasmic expression