Table 1.
Demographic and clinical characteristics of SNIP patients included in the study
| Characteristics | Total | Spanish | Polish | p-valuea |
|---|---|---|---|---|
| SNIPs | SNIPs | SNIPs | ||
| (n = 79) | (n = 46) | (n = 33) | ||
| No. (%)a | No. (%) | No. (%) | ||
| Age at diagnosis | 0.460 | |||
| Mean (SD) | 56.2 (16.1) | 55.0 (15.0) | 57.8 (17.7) | |
| Range | 19–91 | 19–85 | 23–91 | |
| Gender | 0.150 | |||
| Male | 53 (67.1) | 34 (73.9) | 19 (57.6) | |
| Female | 26 (32.9) | 12 (26.1) | 14 (42.4) | |
| Period of diagnosis | < 0.001 | |||
| 1995–2000 | 7 (8.9) | 7 (15.2) | 0 ( 0.0) | |
| 2001–2006 | 17 (21.5) | 17 (37.0) | 0 ( 0.0) | |
| 2007–2012 | 24 (30.4) | 22 (47.8) | 2 ( 6.1) | |
| 2013–2017 | 31 (39.2) | 0 ( 0.0) | 31 (93.9) | |
| Tobacco use | 0.010 | |||
| Never smoker | 33 (41.8) | 13 (28.3) | 20 (60.6) | |
| Ever smoker | 44 (55.7) | 31 (67.4) | 13 (39.4) | |
| Missing | 2 (2.5) | 2 (4.3) | 0 (0.0) | |
| Alcohol use | 0.616 | |||
| Never drinker | 56 (70.9) | 33 (71.7) | 23 (69.7) | |
| Ever drinker | 21 (26.6) | 11 (23.9) | 10 (30.3) | |
| Missing | 2 (2.5) | 2 (4.3) | 0 (0.0) | |
| Previous history of HPV-related pathology | 1.000 | |||
| Yes | 3 (3.8) | 2 (4.3) | 1 (3.0) | |
| No | 74 (93.7) | 42 (91.3) | 32 (97.0) | |
| Missing | 2 (2.5) | 2 (4.3) | 0 (0.0) | |
| Krouse classification | < 0.001 | |||
| 1 | 33 (41.8) | 28 (60.9) | 5 (15.2) | |
| 2 | 23 (29.1) | 11 (23.9) | 12 (36.4) | |
| 3 | 16 (20.3) | 3 (6.5) | 13 (39.4) | |
| 4 | 4 (5.1) | 1 (2.2) | 3 (9.1) | |
| Missing | 3 (3.8) | 3 (6.5) | 0 (0.0) | |
| Transitionalepithelium | 0.015 | |||
| Absence | 19 (24.1) | 16 (34.8) | 3 ( 9.1) | |
| Presence | 60 (75.9) | 30 (65.2) | 30 (90.9) | |
| Squamousepithelium | 0.001 | |||
| Absence | 45 (57.0) | 19 (41.3) | 26 (78.8) | |
| Presence | 34 (43.0) | 27 (58.7) | 7 (21.2) | |
| Columnarepithelium | 0.316 | |||
| Absence | 23 (29.1) | 11 (23.9) | 12 (36.4) | |
| Presence | 56 (70.9) | 35 (76.1) | 21 (63.6) | |
| Hyper-parakeratosis | 1 | |||
| Absence | 76 (96.2) | 44 (95.7) | 32 (97.0) | |
| Presence | 3 (3.8) | 2 ( 4.3) | 1 ( 3.0) | |
| Papillar or exophytic lesion adjacent to SNIP | < 0.001 | |||
| Absence | 61 (77.2) | 44 (95.7) | 17 (51.5) | |
| Presence | 18 (22.8) | 2 ( 4.3) | 16 (48.5) | |
| Polymorphonuclear neutrophil inflammatory intralesional infiltrate | 1.000 | |||
| Absence | 2 (2.5) | 1 ( 2.2) | 1 ( 3.0) | |
| Presence | 77 (97.5) | 45 (97.8) | 32 (97.0) | |
| Polymorphonuclear neutrophil inflammatory perilesional infiltrate | 0.418 | |||
| Absence | 1 (1.3) | 0 ( 0.0) | 1 ( 3.0) | |
| Presence | 78 (98.7) | 46 (100.0) | 32 (97.0) | |
| Recurrence | 0.268 | |||
| No | 59 (74.7) | 31 (67.4) | 28 (84.8) | |
| Yes | 17 (21.5) | 12 (26.1) | 5 (15.2) | |
| Missing | 3 (3.8) | 3 (6.5) | 0 ( 0.0) | |
| Months of follow up | ||||
| Median | 52.83 | 76.63 | 39.1 | 0.003b |
| Range | 0.23–174.33 | 0.23–174.33 | 6.27–66.47 | |
| Months to recurrence | 0.469b | |||
| Median | 14 | 17 | 4 | |
| Range | 3-83 | 9-83 | 3-36 | |
| Progression to invasive cancer | 0.502 | |||
| No | 74 (93.7) | 41 (89.1) | 33 (100.0) | |
| Yes | 2 (2.5) | 2 (4.3) | 0 ( 0.0) | |
| Missing | 3 (3.8) | 3 ( 6.5) | 0 ( 0.0) | |
| HPV positivity | 1.000 | |||
| No | 75 (94.9) | 44 (95.7) | 31 (93.9) | |
| Yes | 4 (5.1) | 2 (4.3) | 2 (6.1) | |
Statistically significant p values given in bold
SNIP Sinonasal Inverted Papilloma, SD standard deviation
aFischer exact test with the exception of age and months to recurrence. where t-student test has been used to compare the median values between populations
bqreg (quantilte regression): test for equality of medians, equivalent for t-test for medians