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. 2020 Aug 6;10:13296. doi: 10.1038/s41598-020-69921-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pre-selection of target antigens and serum dilution for DTU-specific serodiagnosis of Chagas disease by Human Chagas-Flow ATE-IgG1. The Euclidean distance (Δ = │TcI − TcVI│, Δ = │TcII − TcI│ and Δ = │TcVI − TcII│) of median reactivity calculated along the titration curves (1:250 to 1:32,000) for serum samples from patients infected with TcI, TcVI and TcII T. cruzi DTUs. The data are presented as differential reactivity expressed as the percentage of positive fluorescent parasites (Δ PPFP). The dotted rectangles (red for TcI, green for TcVI and blue for TcII) underscore the pair of attributes (“target antigens” & “serum dilutions”) with higher delta reactivity to segregate subgroups of Chagas disease patients. Gray background highlights the pre-selected pairs of attributes (“TI 2,000, “TI 4,000), (“EI 1,000”, “EI 2,000”), (“AVI 8,000, “AVI 16,000”) and (“TVI 4,000”, “TVI 8,000”) for further performance evaluation applied to the DTU-specific diagnosis of Chagas disease.