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The effect of TMP pretreatment on expression of vascular endothelial growth factor (VEGF) by immunohistochemical staining (×100). The amount of brown staining reflects the level of VEGF expression and hence, the angiogenesis status in the tissue. (A): Control group; (B): Indomethacin-exposed group; (C): omeprazole-pretreated group; TMP-pretreated groups at doses 15 and 30 mg/kg (D and E respectively); (F): TMP-pretreated group at dose 60 mg/kg; (G): TMP-alone treated group.
