MorphEUS accurately predicts pathways of action of compounds when blinded to mechanism of action. (A) cKNN profiles of broad drug categories and (B) individual drugs for compounds with anti-TB activities (unk, unknown). Each column corresponds to a different compound or treatment dose. From left to right, joint dose profile (JP) for DG167, JSF-3825, JSF-2019; high dose profile (HD) for JSF-2019; and low dose (LD) profile for JSF-2019: n = 7,300, 7,160, 7,742, 7,742, 5,150, and 2,592 respectively. The most similar drug for each MorphEUS classification is indicated by the red asterisk.