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. 2020 Aug 7;11:3981. doi: 10.1038/s41467-020-17718-z

Fig. 3. Two-sample Mendelian randomization analysis for casual associations between TSH and thyroid cancer and between TSH and goiter.

Fig. 3

a. Two-sample MR between TSH and thyroid cancer based on summary statistics from the meta-analysis of HUNT and ThyroidOmics (n = 106,360) for TSH and from the meta-analysis of UKBB27,28, MGI26, deCODE and four other case–control data sets with European ancestry as reported in Gudmundsson et al.19 for thyroid cancer association (cases/controls = 4,146/731,903). b TSH and goiter based on summary statistics from the same TSH meta-analysis as above and from the GWAS of UKBB27,28 for goiter association (N case = 1,143, N control = 391,429) The crosshairs on the plots represent the 95% confidence intervals for each SNP-TSH or SNP-outcome association. The variant on the top left corner is the rare nonsynonymous variant B4GALNT3 p.R724W (rs145153320). N: sample size. N case: sample size of cases. N control: sample size of controls.