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The necroptosis pathway and mechanism of action of small molecule necroptosis inhibitors. Two inhibitors of the necroptotic pathway were utilized in this study: GSK′872, which inhibits RIP3 kinase activity (21, 22), and necrosulfonamide (NSA), which inhibits downstream effector functions of MLKL via covalent reaction with human MLKL residue Cys86 (19, 23).
