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. 2020 Aug 7;10:13354. doi: 10.1038/s41598-020-70368-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heatmap plot of top 10 up and downregulated DEGs in asthma. Expression values for each DEG (row) are normalized across all the samples (columns). Hierarchical clustering using Euclidean distances was employed for both rows and columns with cluster dendrograms presented along the left and top sides of the plot. The categorical annotation bars (above the heatmap) show the column annotations for age, gender and disease status. The location of each gene on its respective chromosome was shown in the right bar (color bands) as row annotation.