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. 2020 Aug 7;11:3953. doi: 10.1038/s41467-020-17740-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Schematic depiction of heart anatomy. b Bar plots and UMAP visualization (gray, low; red, high expression) showing examples of cell subtype-specific expression (arrow). c Immunofluorescence staining of heart from the Pdgfrb^GFP reporter line for WIF1, NG2, and PECAM1, focused on the cardiac valve and hinge region. d RNAscope staining for Pdgfra, Wif1, and Dcn, focused on the cardiac valve region. Arrowheads: valve interstitial cells; arrows: pericytes; HR: hinge region, V: valve leaflet. Scale bar: 100 µm. e Venn diagram showing skeletal muscle perimysial- and heart valve interstitial cell co-enriched genes. f Examples of co-enriched genes presented as bar plots and UMAP (gray, low; red, high expression). Asterisk: gene list of commonly enriched genes (see also Supplementary Table 2).